The Funniest (and Furriest) of the Funny Pages
A website that nicely sums up the impact Calvin & Hobbes had on comics, and why, 10 years after the end of its run, it's still lamented.
If you think about it, Calvin was really quite an anomaly in popular entertainment -- not just in comics, but in anything, be it movies, TV, etc. He has no friends, and no extracurricular activities; the only people he ever sees are his parents, who he has a strained relationship with, and Moe, Susie, Rosalyn, and Miss Wormwood, all of whom he detests and all of whom detest him. The only person he ever has any real interaction with exists only in his head.
Huge kudos to Bill Watterson for graphically murdering a guy in the funny papers.